|
| Status |
Public on May 15, 2024 |
| Title |
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defense in KRAS-mutant lung cancer |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Investigate how loss of Lkb1 in the context of KRAS mutation alters metablism in cancer and contributes in cancer aggressiveness
|
| |
|
| Overall design |
Parental and reconstituted H460 cells lines were grown and propagated in RPMI-10%FBS media, followed by ATAC-seq profiling.
|
| |
|
| Contributor(s) |
Chronis C, Lee H, Joves K, Kim JY |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 25, 2024 |
| Last update date |
May 15, 2024 |
| Contact name |
Constantinos chronis |
| E-mail(s) |
chronis@uic.edu
|
| Phone |
3123558012
|
| Organization name |
UIC
|
| Department |
Biochemistry and Molecular Genetics
|
| Lab |
ChronisLab
|
| Street address |
900 S Ashland Ave, Mbrb 2370
|
| City |
CHICAGO |
| State/province |
IL |
| ZIP/Postal code |
60607 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA1104567 |
Less...
More...