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| Status |
Public on May 08, 2024 |
| Title |
Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (BPA) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Pregannt Cyp19-EGFP mice (maintained on a soybean free mouse chow diet) were treated with either 50μg/kg/day Bsiphenol A or vehicle (ethinol in peanut oil) between gestational days (GD) 10.5-14.5. On GD15.5, fetuses were dissected and sex determined by SRY genotyping. Fetuses were obtained from different dams.
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| Overall design |
To investigate the effect of prenatal BPA expsoure on offspring RNA expression, Cyp19-EGFP mice dams were treated with either 50μg/kg BPA or vehicle (peanut oil) at GD10.5-GD14.5. The cortex of the brain was rapidly dissected from the fetuses at GD15.5.
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| Contributor(s) |
Boon W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 01, 2024 |
| Last update date |
May 08, 2024 |
| Contact name |
Wah Chin Boon |
| E-mail(s) |
wah.chin.boon@florey.edu.au
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| Phone |
0407640787
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| Organization name |
The Florey Institute of Neuroscience and Mental Health
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| Street address |
30 Royal Parade Parkville
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| City |
Melbourne |
| State/province |
Victoria |
| ZIP/Postal code |
3052 |
| Country |
Australia |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1106913 |
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