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| Status |
Public on May 08, 2024 |
| Title |
Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Migraine is primarily mediated via CGRP signaling on various tissues to induce pain and other migraine symptoms. We characterize the role of migraine related CGRP signaling on meningeal lymphatic vessels from mouse meningeal lymphatic tissue.
In this dataset, we include the expression data obtained from lyve-1 positive meningeal lymphatic endothelial cells from Lyve-1 cre mediated HA-tagged ribosomes from mice with the NTG mediated model of migraine. These data are used to obtain 700 genes that are differentially expressed in meningeal lymphatic tissue in response to NTG induced migraine.
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| Overall design |
6 Total samples were analyzed. We generated the following pairwise comparisons using PowerExpress: NTG vs Vehicle
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| Contributor(s) |
Nelson-Maney N, Balint L, Beeson A, Serafin D, Kistner B, Douglas E, Siddiqui A, Tauro A, Caron K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 03, 2024 |
| Last update date |
May 08, 2024 |
| Contact name |
Nathan Nelson-Maney |
| E-mail(s) |
nathan_nelson-maney@med.unc.edu
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| Phone |
5088689508
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| Organization name |
UNC Chapel Hill
|
| Department |
Cell Biology and Physiology
|
| Lab |
Caron Lab
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| Street address |
111 mason farm road
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| City |
Chapel Hill |
| State/province |
North Carolina |
| ZIP/Postal code |
27599 |
| Country |
USA |
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| Platforms (1) |
| GPL33894 |
[Clariom_S_Mouse_HT] Affymetrix Clariom S Assay HT, Mouse [Brainarray Entrez version 22] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1107583 |
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