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Series GSE266567 Query DataSets for GSE266567
Status Public on May 10, 2024
Title Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, and skeletal muscle tissue from mice fed high-fat, high-sugar diet. [skeletal muscle]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Perform RNAseq with existing frozen mouse DO tissues from ~500 DO mice were sensitized on a HFHS diet (Keller, Gatti et al. 2018). The same mice have been extensively characterized for T2D-relevant clinical phenotypes, ex-vivo islet function, and other features including microbiome profiling. Gene expression and proteomic profiling has already been completed in islets. We will collect and analyze the genetic architecture of gene expression in liver, adipose, skeletal muscle. Tissues will be sent to JAX Bar Harbor from Alan Attieā€™s lab. These tissues were from the same mice used for transcriptome analysis of islets (Genetics May 1, 2018 vol. 209 no. 1 335-356)
 
Overall design transcription profiling by high-throughput sequencing design
 
Contributor(s) Churchill GA, Baker CN
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Submission date May 03, 2024
Last update date May 10, 2024
Contact name Gary Churchill
E-mail(s) Gary.Churchill@jax.org
Phone 207-288-6000
Organization name The Jackson Laboratory
Street address 600 Main St
City Bar Harbor
State/province Maine
ZIP/Postal code 04609
Country USA
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (474)
GSM8250671 DO021_F_17_GT20_00377_skeletal muscle
GSM8250672 DO022_F_17_GT20_00475_skeletal muscle
GSM8250673 DO023_F_17_GT20_00504_skeletal muscle
Relations
BioProject PRJNA1107601

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE266567_counts_matrix.csv.gz 31.7 Mb (ftp)(http) CSV
GSE266567_mrna_annots.csv.gz 643.1 Kb (ftp)(http) CSV
GSE266567_vst_matrix.csv.gz 69.1 Mb (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA

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