|
| Status |
Public on Mar 30, 2012 |
| Title |
Inhibition of Bcl6-SMRT/NCoR interactions by an inhibitory peptide affects inflammatory pathways |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Using microarrays, we compared the changes in levels of gene expression between wild type mouse bone marrow derived macrophages upon treatment with the Bcl6 peptide inhibitor, RI-BPI, that specifically blocks interaction between BCL6 and the co-repressors NCoR or SMRT.
|
| |
|
| Overall design |
Total RNA was obtained from cultered wild type primary bone marrow-derived macrophages that were treated with either 5 μM control or RI-BPI peptide in MSF media for 12 hours.
|
| |
|
| Contributor(s) |
Yu RT, Barish GD, Evans RM |
| Citation(s) |
22465074 |
| Submission date |
Feb 01, 2011 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Ruth T Yu |
| Organization name |
Salk Institute
|
| Department |
Gene Expression Lab
|
| Lab |
Ronald Evans
|
| Street address |
10010 N Torrey Pines Rd
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (6)
|
| GSM665096 |
wildtype macrophages treated with control peptide, technical replicate 1 |
| GSM665097 |
wildtype macrophages treated with control peptide, technical replicate 2 |
| GSM665098 |
wildtype macrophages treated with control peptide, technical replicate 3 |
| GSM665099 |
wildtype macrophages treated with RI-BPI peptide, technical replicate 1 |
| GSM665100 |
wildtype macrophages treated with RI-BPI peptide, technical replicate 2 |
| GSM665101 |
wildtype macrophages treated with RI-BPI peptide, technical replicate 3 |
|
| This SubSeries is part of SuperSeries: |
| GSE27060 |
A Bcl6-Smrt/Ncor repression program controls atherosclerosis |
|
| Relations |
| BioProject |
PRJNA142045 |
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