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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 30, 2011 |
| Title |
Expression data from murine vaginal samples following adjuvant treatment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Vaccine research today is focused on using safer, highly purified or recombinant antigens with poor immunogenicity, which has created a need for potent adjuvants. Rational design of effective and safe mucosal adjuvants for human use necessitates a thorough understanding of the mode of action of successful candidate adjuvants.
We used microarray to comprehend the molecular signatures of mucosal adjuvants in the mouse vagina. The adjuvants studied, CpG-ODN and α-GalCer have previously been shown to be potent mucosal adjuvants in mice when administrered together with a glycoprotein from HSV-2.
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| Overall design |
Two individual experiments were performed, called ES1 and ES2, each experiment contained 4 groups of mice. All mice were pre-treated with progesteron (DP) before intravaginally recieveing either CpG ODN, α-GalCer or their respective buffers, PBS and PBS/Tween. Vaginas were excised at 3 different time-points; 4h, 24h and 48h following adjuvant delivery.
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| Contributor(s) |
Lindqvist M, Veerla S, Nookaew I |
| Citation(s) |
21666746 |
| Submission date |
Feb 08, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Ali Mohaghegh Harandi |
| E-mail(s) |
ali.harandi@microbio.gu.se
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| Phone |
+46(0)317866229
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| Organization name |
University of Gothenburg
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| Department |
Microbiology and Immunology
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| Street address |
Medicinaregatan 7A
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| City |
Gothenburg |
| ZIP/Postal code |
405 30 |
| Country |
Sweden |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (47)
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| GSM671107 |
ES2, G1, M2, V4h |
| GSM671108 |
ES1, G1, M1, V24h |
| GSM671109 |
ES1, G1, M2, V24h |
| GSM671110 |
ES2, G1, M1, V24h |
| GSM671111 |
ES2, G1, M2, V24h |
| GSM671112 |
ES1, G1, M1, V48h |
| GSM671113 |
ES1, G1, M2, V48h |
| GSM671114 |
ES2, G1, M1, V48h |
| GSM671115 |
ES1, G2, M1, V4h |
| GSM671116 |
ES1, G2, M2, V4h |
| GSM671117 |
ES2, G2, M1, V4h |
| GSM671118 |
ES2, G2, M2, V4h |
| GSM671119 |
ES1, G2, M1, V24h |
| GSM671120 |
ES1, G2, M2, V24h |
| GSM671121 |
ES2, G2, M1, V24h |
| GSM671122 |
ES2, G2, M2, V24h |
| GSM671123 |
ES1, G2, M1, V48h |
| GSM671124 |
ES1, G2, M2, V48h |
| GSM671125 |
ES2, G2, M1, V48h |
| GSM671126 |
ES2, G2, M2, V48h |
| GSM671127 |
ES1, G3, M1, V4h |
| GSM671128 |
ES1, G3, M2, V4h |
| GSM671129 |
ES2, G3, M1, V4h |
| GSM671130 |
ES2, G3, M2, V4h |
| GSM671131 |
ES1, G3, M1, V24h |
| GSM671132 |
ES1, G3, M2, V24h |
| GSM671133 |
ES2, G3, M1, V24h |
| GSM671134 |
ES2, G3, M2, V24h |
| GSM671135 |
ES1, G3, M1, V48h |
| GSM671136 |
ES1, G3, M2, V48h |
| GSM671137 |
ES2, G3, M1, V48h |
| GSM671138 |
ES2, G3, M2, V48h |
| GSM671139 |
ES1, G4, M1, V4h |
| GSM671140 |
ES1, G4, M2, V4h |
| GSM671141 |
ES2, G4, M1, V4h |
| GSM671142 |
ES2, G4, M2, V4h |
| GSM671143 |
ES1, G4, M1, V24h |
| GSM671144 |
ES1, G4, M2, V24h |
| GSM671145 |
ES2, G4, M1, V24h |
| GSM671146 |
ES2, G4, M2, V24h |
| GSM671147 |
ES1, G4, M1, V48h |
| GSM671148 |
ES1, G4, M2, V48h |
| GSM671149 |
ES2, G4, M1, V48h |
| GSM671150 |
ES2, G4, M2, V48h |
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| Relations |
| BioProject |
PRJNA137563 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE27149_RAW.tar |
190.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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