|
| Status |
Public on Feb 09, 2011 |
| Title |
Expression data from Tregs purified from WT-CD3KO or IIKO-CD3KO chimeras |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Disruption of TCR /MHC class II interactions leads rapidly to alterations of the common CD4 Treg transcriptional signature
Self-deprived, non-functional Tregs were compare to fully functional Tregs by microarrays.
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| |
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| Overall design |
CD3ε-/- mice were lethally irradiated and their immune system reconstituted with WT mouse (WT-CD3KO chimeras) or IIKO mouse (IIKO-CD3KO) Bone Marrow cells. Twenty eight days later, peripheral Tregs from these chimeras were purified for RNA extraction and hybridization on Affymetrix microarrays.
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| |
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| Contributor(s) |
Lucas B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 08, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Florent Dumont |
| E-mail(s) |
florent.dumont@u-psud.fr
|
| Organization name |
Université Paris-Saclay
|
| Street address |
17 avenue des sciences
|
| City |
91400 Orsay |
| State/province |
Ile de France |
| ZIP/Postal code |
91400 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (8)
|
| GSM671232 |
Tregs purified from WT-CD3KO chimera, Biological Rep1 |
| GSM671233 |
Tregs purified from WT-CD3KO chimera, Biological Rep2 |
| GSM671234 |
Tregs purified from WT-CD3KO chimera, Biological Rep3 |
| GSM671235 |
Tregs purified from WT-CD3KO chimera, Biological Rep4 |
| GSM671236 |
Tregs purified from IIKO-CD3KO chimera, Biological Rep1 |
| GSM671237 |
Tregs purified from IIKO-CD3KO chimera, Biological Rep2 |
| GSM671238 |
Tregs purified from IIKO-CD3KO chimera, Biological Rep3 |
| GSM671239 |
Tregs purified from IIKO-CD3KO chimera, Biological Rep4 |
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| This SubSeries is part of SuperSeries: |
| GSE27153 |
Expression data from self-deprived regulatory CD4 T cells |
|
| Relations |
| BioProject |
PRJNA142087 |
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