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| Status |
Public on Aug 15, 2011 |
| Title |
Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene expression (mRNA) profiling of human ependymomas
Despite the histological similarity of ependymomas from throughout the neuraxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymoma. Group-A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, secondary metastasis, and death as compared to Group-B patients. Identification and optimization of immunohistochemical markers for PF ependymoma subgroups allowed validation of our findings on a third independent group of tumors using a human ependymoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.
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| |
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| Overall design |
We analyzed 102 primary ependymomas on the Affymetrix Exon 1.0ST platform (Gene Level).
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| Contributor(s) |
Mack SC, Witt H, Taylor MD, Pfister SM |
| Citation(s) |
21840481 |
| Submission date |
Feb 13, 2011 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Stephen Mack Christopher |
| E-mail(s) |
stevemack.work@gmail.com
|
| Phone |
2163182292
|
| Organization name |
Baylor College of Medicine
|
| Department |
Pediatrics
|
| Lab |
Stephen Mack Lab
|
| Street address |
1102 Bates Avenue C1030.02
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
770030 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL5175 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (102)
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| Relations |
| BioProject |
PRJNA137319 |
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