|
| Status |
Public on Feb 25, 2012 |
| Title |
Identification of hypoxia regulated HIF-1A and HIF-2A specific target genes in Glioblastoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
HIF-1A and HIF-2A regulate both overlapping and unique target genes in response to hypoxia.
In this dataset, we identify specific HIF-1A and HIF-2A target genes in glioblastoma cells.
|
| |
|
| Overall design |
12 samples were analysed comprising 4 experimental conditions (normoxia scr, hypoxia scr, hypoxia siHIF1, hypoxia siHIF2) in triplicate. We made pairwise comparisons between the averages of each triplicate set to normoxia scr using the Partek suite.
|
| |
|
| Contributor(s) |
Koh M, Lemos R Jr, Liu X, Powis G |
| Citation(s) |
21512133 |
| Submission date |
Feb 25, 2011 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Mei Yee Koh |
| E-mail(s) |
mykoh@mdanderson.org
|
| Organization name |
U.T. M.D. Anderson Cancer Center
|
| Department |
Experimental Therapeutics
|
| Street address |
1515 Holcombe Blvd
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77021 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL5175 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version] |
|
| Samples (12)
|
| GSM679835 |
Hypoxic cells with non-targeting siRNA replicate 1 |
| GSM679836 |
Hypoxic cells with non-targeting siRNA replicate 2 |
| GSM679837 |
Hypoxic cells with non-targeting siRNA replicate 3 |
| GSM679838 |
Hypoxic cells with HIF-1A siRNA replicate 1 |
| GSM679839 |
Hypoxic cells with HIF-1A siRNA replicate 2 |
| GSM679840 |
Hypoxic cells with HIF-1A siRNA replicate 3 |
| GSM679841 |
Hypoxic cells with HIF-2A siRNA replicate 1 |
| GSM679842 |
Hypoxic cells with HIF-2A siRNA replicate 2 |
| GSM679843 |
Hypoxic cells with HIF-2A siRNA replicate 3 |
| GSM679844 |
Normoxic cells with non-targeting siRNA replicate 1 |
| GSM679845 |
Normoxic cells with non-targeting siRNA replicate 2 |
| GSM679846 |
Normoxic cells with non-targeting siRNA replicate 3 |
|
| Relations |
| BioProject |
PRJNA137109 |
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