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| Status |
Public on Oct 08, 2011 |
| Title |
The addition of chromosome 8 leads to characteristic dysregulation of gene expression on all chromosome and transformed-associated phenotypes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To examain effects of trisomy 8 on gene expression in normal human cells, we have employed whole genome microarray expression profiling. To study the effects of aneuploidy in normal human cells, we generated cells which are artificially trisomic chromosome 8 (trisomy 8) using human primary fibroblast cells by microcell-mediated chromosome transfer (HE35tri8 clones).
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| Overall design |
Gene expression in trisomy 8 clones (HE35tri8-1, 2 and3) and euploid clones (HE35-1, 2 and 4). Three independent experiments were performed at each clone.
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| Contributor(s) |
Daino K, Kashino G, Kugoh H, Oshimura M, Shimada Y, Tano K, Watanabe M |
| Citation(s) |
21980425 |
| Submission date |
Mar 21, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Hisakatsu Nawata |
| E-mail(s) |
chromosometransfer@yahoo.co.jp
|
| Organization name |
Kyoto University
|
| Department |
Medicine
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| Lab |
Radiation Biology
|
| Street address |
2-1010
|
| City |
osaka |
| ZIP/Postal code |
590-0494 |
| Country |
Japan |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (18)
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| GSM694236 |
Human embryonic diploid cell clone1 sample1 |
| GSM694237 |
Human embryonic diploid cell clone1 sample2 |
| GSM694238 |
Human embryonic diploid cell clone1 sample3 |
| GSM694239 |
Human embryonic diploid cell clone2 sample1 |
| GSM694240 |
Human embryonic diploid cell clone2 sample2 |
| GSM694241 |
Human embryonic diploid cell clone2 sample3 |
| GSM694242 |
Human embryonic diploid cell clone4 sample1 |
| GSM694243 |
Human embryonic diploid cell clone4 sample2 |
| GSM694244 |
Human embryonic diploid cell clone4 sample3 |
| GSM694245 |
Human embryonic artificial trisomy8 cell clone1 sample1 |
| GSM694246 |
Human embryonic artificial trisomy8 cell clone1 sample2 |
| GSM694247 |
Human embryonic artificial trisomy8 cell clone1 sample3 |
| GSM694248 |
Human embryonic artificial trisomy8 cell clone2 sample1 |
| GSM694249 |
Human embryonic artificial trisomy8 cell clone2 sample2 |
| GSM694250 |
Human embryonic artificial trisomy8 cell clone2 sample3 |
| GSM694251 |
Human embryonic artificial trisomy8 cell clone3 sample1 |
| GSM694252 |
Human embryonic artificial trisomy8 cell clone3 sample2 |
| GSM694253 |
Human embryonic artificial trisomy8 cell clone3 sample3 |
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| Relations |
| BioProject |
PRJNA139721 |
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