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| Status |
Public on Jun 01, 2011 |
| Title |
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells (ChIP-seq) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
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| Summary |
We report that hyperglycemia-mediated induction of genes and pathways associated to endothelial dysfunction occur through modulation of acetylated H3K9/K14 inversely correlated with methyl-CpG content.
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| Overall design |
Examination of H3K9/K14 histone acetylation and DNA methylation in hyperglycemic conditions.
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| Contributor(s) |
Pirola L, Balcerczyk A, Tothill R, Haviv I, Kaspi A, Lunke S, Karagiannis T, Tonna S, Kowalczyk A, Beresford-Smith B, Zieman M, Kelong M, Hongyu Z, Jinfeng S, Zhu J, El-Osta A |
| Citation(s) |
21890681 |
| Submission date |
May 12, 2011 |
| Last update date |
May 15, 2019 |
| Contact name |
Assam El-Osta |
| Organization name |
Baker Heart and Diabetes Institute
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| Lab |
Human Epigenetics
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| Street address |
75 Commercial Road
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| City |
Melbourne |
| ZIP/Postal code |
3004 |
| Country |
Australia |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (13)
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| Relations |
| SRA |
SRP006775 |
| BioProject |
PRJNA139967 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE29251_H3K914Ac_HGvLG_DN_peaks.bed.gz |
44.1 Kb |
(ftp)(http) |
BED |
| GSE29251_H3K914Ac_HGvLG_UP_peaks.bed.gz |
105.0 Kb |
(ftp)(http) |
BED |
| GSE29251_MM_HGvLG_DN_peaks.bed.gz |
59.5 Kb |
(ftp)(http) |
BED |
| GSE29251_MM_HGvLG_UP_peaks.bed.gz |
79.9 Kb |
(ftp)(http) |
BED |
| GSE29251_RAW.tar |
10.9 Gb |
(http)(custom) |
TAR (of BAM) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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