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| Status |
Public on Jan 09, 2012 |
| Title |
Comparison of gene expression profiles of MafF-/-: MafG-/-: MafK-/- embryos and MafF-/-: MafG+/+: MafK-/- embyos |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
MafF-/-: MafG+/+: MafK-/- mice are viable, while MafF-/-: MafG-/-: MafK-/- mice are embryonic lethal. To get an insight into the cause of the lethality of small Maf triple knockout mice, transcriptome analysis was performed using whole embyos of MafF-/-: MafG-/-: MafK-/- at E10.5 and those of MafF-/-: MafG+/+: MafK-/- at E9.5 or E10.5.
Because MafF-/-: MafG-/-: MafK-/- embryos exhibit growth retardation, the gene expression profile of MafF-/-: MafG-/-: MafK-/- embryos at E10.5 was compared with that of MafF-/-: MafG+/+: MafK-/- embyos at E9.5. The gene expression profile of MafF-/-: MafG+/+: MafK-/- embryos at E10.5 was also examined as an alternative control.
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| Overall design |
Total RNA was prepared from pooled three embryos for each sample.
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| Contributor(s) |
Yamazaki H, Katsuoka F, Motohashi H, Engel JD, Yamamoto M |
| Citation(s) |
22158967 |
| |
| Submission date |
May 26, 2011 |
| Last update date |
May 10, 2018 |
| Contact name |
Masayuki Yamamoto |
| E-mail(s) |
masiyamamoto@med.tohoku.ac.jp
|
| Phone |
81-22-717-8084
|
| Organization name |
Tohoku University Graduate School of Medicine
|
| Department |
Medical Biochemistry
|
| Street address |
2-1 Seiryo-machi, Aoba-ku
|
| City |
Sendai |
| ZIP/Postal code |
980-8575 |
| Country |
Japan |
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| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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| Samples (3) |
| GSM731854 |
E10.5 MafF-/-: MafG-/-: MafK-/- embryos (no.1) |
| GSM731855 |
E10.5 MafF-/-: MafG+/+: MafK-/- embryos (no.2) |
| GSM731856 |
E9.5 MafF-/-: MafG+/+: MafK-/- embryos (no.3) |
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| Relations |
| BioProject |
PRJNA141327 |
