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| Status |
Public on Apr 01, 2012 |
| Title |
Female- and male-specific transcriptomic and epigenetic placental signatures in response to a maternal high fat diet in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Overnutrition during pregnancy influences the future health of the offspring, with outcomes differing depending on the child’s sex. The placenta is involved in the programming of obesity, type 2 diabetes and cardiovascular disease. Sex-specific adaptation of the placenta may be central to the differences in fetal growth and survival. The impact of diet and fetal sex on placental gene expression and epigenetic marks was investigated in mice fed a high-fat (HFD) or a control diet (CD), during the first 15 days of gestation
Microarrays analysis revealed that expression was affected by maternal diet and was sexually dimorphic.
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| Overall design |
We analyzed the placentae of 4 mice litters fed with an high-fat diet (HFD) and 4 with a control diet (CD). For each litter, the placenta transcriptome was analysed according to the foetus sex using the Affymetrix Human Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool. No technical replicates were performed.
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| Contributor(s) |
Gabory A, Gothié J, Ferry L, Vigé A, Fleur C, Gallou-Kabani C, Gross M, Fajardy I, Vambergue A, Lesage J, Reusens B, Vieau D, Remacle C, Jouneau L, Jais J, Junien C |
| Citation(s) |
23144842 |
| Submission date |
May 27, 2011 |
| Last update date |
Mar 06, 2018 |
| Contact name |
Jean-Philippe Jais |
| E-mail(s) |
jean-philippe.jais@parisdescartes.fr
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| Organization name |
Université Paris Descartes - Hopital Necker-Enfants Malades
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| Lab |
SBIM
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| Street address |
149 rue de Sevres
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| City |
Paris |
| ZIP/Postal code |
75743 cedex 15 |
| Country |
France |
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| Platforms (1) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (16)
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| GSM732413 |
Placenta male, litter P19 |
| GSM732414 |
Placenta female, litter P22 |
| GSM732415 |
Placenta male, litter P22 |
| GSM732416 |
Placenta female, litter P42 |
| GSM732417 |
Placenta male, litter P42 |
| GSM732418 |
Placenta female, litter P46 |
| GSM732419 |
Placenta male, litter P46 |
| GSM732420 |
Placenta female, litter P52 |
| GSM732421 |
Placenta male, litter P52 |
| GSM732422 |
Placenta female, litter P62 |
| GSM732423 |
Placenta male, litter P62 |
| GSM732424 |
Placenta female, litter P76 |
| GSM732425 |
Placenta male, litter P76 |
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| Relations |
| BioProject |
PRJNA141421 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE29585_RAW.tar |
349.2 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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