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Series GSE29817 Query DataSets for GSE29817
Status Public on Jul 19, 2011
Title Membranous Expression of Ectodomain Isoforms of the Epidermal Growth Factor Receptor (EGFR) Predicts Outcome after Chemoradiotherapy of Lymph Node Negative Cervical Cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We compared the prognostic significance of ectodomain isoforms of the epidermal growth factor receptor (EGFR), which lack the tyrosine kinase (TK) domain, with that of the full length receptor and its autophosphorylation status in cervical cancers treated with conventional chemoradiotherapy.
We further explored signaling pathways that were correlated with high expression of ectodomain isoforms by gene expression analysis of 110 of the tumors, and validated the results in an independent cohort of 41 tumors.
 
Overall design Pathways associated with the expression of ectodomain isoforms were studied by gene expression analysis with Illumina beadarrays in 110 patients and validated in an independent cohort of 41 patients.
 
Contributor(s) Halle C, Lando M, Svendsrud DH, Clancy T, Holden M, Sundfør K, Kristensen GB, Holm R, Lyng H
Citation(s) 21737508
Submission date Jun 08, 2011
Last update date Jun 24, 2020
Contact name Heidi Lyng
E-mail(s) heidi.lyng@rr-research.no
Phone 4722781478
Organization name Oslo University Hospital
Department Department of Radiation Biology
Street address Montebello
City Oslo
ZIP/Postal code 0310
Country Norway
 
Platforms (1)
GPL6884 Illumina HumanWG-6 v3.0 expression beadchip
Samples (151)
GSM678702 Cervical tumor biopsy, P-002
GSM678703 Cervical tumor biopsy, P-004
GSM678704 Cervical tumor biopsy, P-005
Relations
BioProject PRJNA140937

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29817_RAW.tar 6.3 Mb (http)(custom) TAR
GSE29817_updated_non-normalized_151Patients.txt.gz 45.4 Mb (ftp)(http) TXT
Processed data included within Sample table

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