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| Status |
Public on Jun 15, 2011 |
| Title |
Gene expression analysis of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of gene expression of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.The hypothesis tested in the present study was that mast cells inhibition or absence impacted prostate tumor development and histotype. Results demonstrate that prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated have a neuroendocrine signature.
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| Overall design |
Total RNA obtained from prostate tumors from 24 wks old TRAMP mice chronically treated with sodium chromoglycate (cromolyn) since 8 wks of age, and from 24 wks old TRAMP KitW-sh mice, compared to untreated 30 wks old TRAMP mice and to non tumoral prostates
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| Contributor(s) |
Pittoni P, Mauri G |
| Citation(s) |
21896641 |
| Submission date |
Jun 14, 2011 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Paola Pittoni |
| E-mail(s) |
paola.pittoni@istitutotumori.mi.it
|
| Phone |
+39 0223903232
|
| Fax |
+39 0223902630
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| Organization name |
IRCCS Istituto Nazionale dei Tumori
|
| Department |
Dept. Experimental Oncology
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| Lab |
Molecular Immunology Unit
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| Street address |
Via Amadeo, 42
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| City |
Milan |
| State/province |
Italy |
| ZIP/Postal code |
20133 |
| Country |
Italy |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE29958 |
Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers. |
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| Relations |
| BioProject |
PRJNA155321 |
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