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| Status |
Public on Jun 12, 2015 |
| Title |
Expression data from pregnant rat hearts |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Hyperhomocysteinemia (HHcy) causes cardiovascular dysfunction and is associated with many complications during pregnancy related to reduced NO bioactivity. The mechanisms of HHcy on the NO-dependent control of myocardial metabolism was compared with L-NAME, which directly inhibits NO bioavailability, treated animals.
We used microarrays to detail the global programme of gene expression underlying hyperhomocysteinemia during pregnancy and identified distinct classes of differentially regulated genes.
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| Overall design |
Female SD rats were mated with male SD rats. Methionine was used to generate hyperhomocysteinemia model. L-NAME was used to generate NO restricted model. After treatment, the left ventricles were harvested for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Song S, Ojaimi C, Hintze TH |
| Citation(s) |
26009634 |
| Submission date |
Jun 29, 2011 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Caroline Ojaimi |
| E-mail(s) |
CAROLINE_OJAIMI@NYMC.EDU
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| Phone |
914-594 4227
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| Organization name |
New York Medical College
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| Street address |
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| City |
Valhalla |
| State/province |
NY |
| ZIP/Postal code |
10595 |
| Country |
USA |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (13)
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| GSM751260 |
control heart, rep 4 |
| GSM751261 |
control heart, rep 5 |
| GSM751262 |
methionine-fed, rep 1 |
| GSM751263 |
methionine-fed, rep 2 |
| GSM751264 |
methionine-fed, rep 3 |
| GSM751265 |
methionine-fed, rep 4 |
| GSM751266 |
L-NAME-fed, rep 1 |
| GSM751267 |
L-NAME-fed, rep 2 |
| GSM751268 |
L-NAME-fed, rep 3 |
| GSM751269 |
L-NAME-fed, rep 4 |
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| Relations |
| BioProject |
PRJNA143575 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30308_RAW.tar |
36.3 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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