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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 11, 2011 |
| Title |
Expression data from mice lacking SIRT3 under dietary stress |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
SIRT3 is a mitochondrial NAD(+)-dependent protein deacetylase, which regulates the enzymatic activity of several mitochondrial proteins.
We used microarrays to identify the differences in gene expression as a result of loss of SIRT3, under standard and high-fat diet conditions
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| Overall design |
Wild-type and SIRT3KO mice were sacrificed at 12weeks of age and RNA was extracted from liver tissue, and hybridized on Affymetrix microarrays, to determine differences in gene expression as a result of diet
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| Contributor(s) |
Hirschey MD, Verdin E |
| Citation(s) |
21856199 |
| Submission date |
Jul 11, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Matthew Hirschey |
| E-mail(s) |
matthew.hirschey@duke.edu
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| Organization name |
Duke University Medical Center
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| Department |
Department of Medicine
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| Lab |
Duke Molecular Physiology Institute
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| Street address |
300 N. Duke Street
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| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27701 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| GSM758182 |
SIRT3KO, standard diet, rep1 |
| GSM758183 |
SIRT3KO, standard diet, rep2 |
| GSM758184 |
SIRT3KO, standard diet, rep3 |
| GSM758185 |
Control, high-fat diet, rep1 |
| GSM758186 |
Control, high-fat diet, rep2 |
| GSM758187 |
Control, high-fat diet, rep3 |
| GSM758188 |
SIRT3KO, high-fat diet, rep1 |
| GSM758189 |
SIRT3KO, high-fat diet, rep2 |
| GSM758190 |
SIRT3KO, high-fat diet, rep3 |
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| Relations |
| BioProject |
PRJNA144471 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30552_RAW.tar |
51.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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