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| Status |
Public on Dec 30, 2013 |
| Title |
Detection of oncoantigens suitable for lung cancer vaccination |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The lung cancer tumor K-rasLA1/ p53 R172HDeltag mouse model was used to identify genes associated to the tumor mass increase in lungs. Those genes were then ranked on the basis of their oncogenic potential using a metadataset encompassing 695 human lung adenocarcinomas and ranking them on the basis of their expression in normal tissues. The genes characterized by the higher oncogenic potential combined to a low expression in normal tissues were selected as putative targets for preclinical studies on lung cancer vaccination.
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| Overall design |
Two prototypic situations (WT, and MUT) were examined using Exon arrays over a three-points time course (10, 20, and 30 weeks old animals), for each time point two/three male and female animals were used. A total of 30 mouse Exon 1.0 arrays were hybridized.
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| Contributor(s) |
Riccardo F, Quaglino E, Arigoni M, Iezzi M, Longo DL, Ercole E, Bicciato S, Nuzzo S, Crispi S, Forni G, Calogero RA, Cavallo F |
| Citation missing |
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| Submission date |
Jul 22, 2011 |
| Last update date |
Mar 06, 2018 |
| Contact name |
Raffaele A Calogero |
| E-mail(s) |
raffaele.calogero@unito.it
|
| Phone |
++39 0116706454
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| Organization name |
University of Torino
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| Department |
Molecular Biotechnology Center
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| Lab |
Bioinformatics and Genomics Unit
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| Street address |
Via Nizza 52
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| City |
Torino |
| State/province |
To |
| ZIP/Postal code |
10126 |
| Country |
Italy |
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| Platforms (1) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA144265 |
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