|
| Status |
Public on Sep 17, 2011 |
| Title |
Transcriptomic Signature of Trophoblast Differentiation in a Human Embryonic Stem Cell Model |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Identification of genes involved in trophoblast differentiation is of great interest in understanding cellular and molecular mechanisms involved in placental development and is relevant clinically to fetal development, fertility, and maternal health. To understand, on a global scale, changes in the transcriptome during the differentiation of hESCs down the trophoblast lineage, a large-scale microarray analysis was performed. This work provides an in vitro functional genomic model with which to identify genes involved in trophoblast development.
|
| |
|
| Overall design |
We investigated differentiation of human embryonic stemcells (hESCs) down the trophoblast lineage by culture with bone morphogenetic protein 4 (BMP4) over a 10-day period and analyze the cell every 2-days.
|
| |
|
| Contributor(s) |
Marchand M, Horcajadas JA, Esteban FJ, McElroy SL, Fisher SJ, Giudice LC |
| Citation(s) |
21368299 |
| Submission date |
Jul 25, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Jose Antonio Martinez-Conejero |
| E-mail(s) |
josn.mc@gmail.com
|
| Organization name |
iGenomix
|
| Street address |
C/ Guadassuar 1, bajo
|
| City |
Valencia |
| ZIP/Postal code |
46015 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (21)
|
|
| Relations |
| BioProject |
PRJNA146311 |
Less...
More...