|
| Status |
Public on Sep 21, 2011 |
| Title |
Expression data from mouse heart deficient of HDAC3 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene expression changes in the heart of MCH3-KO mouse (HDAC3 f/f, Muscle Creatine Kinase-Cre) versus control WT mouse (HDAC3 f/f).
Histone deacetylases (HDACs) play important roles in cardiac development and function. We show here that mice deficient of HDAC3 in heart and skeletabl muscle are relatively normal on normal chow, but develop hypertrophic cardiomyopathy and heart failure that leads to death on high-fat diet. This microarray experiment is to explore the underlying molecular mechanism.
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| Overall design |
Hearts from 6-weeks old WT and MCH3-KO C57BL/6 mice (n=4 in each group, male) on normal chow were subjected to RNA extraction and Affymetrix Mouse Gene 1.0ST analysis.
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| Contributor(s) |
Sun Z, Lazar MA |
| Citation(s) |
21808063 |
| Submission date |
Aug 08, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Zheng Sun |
| E-mail(s) |
zheng.sun@bcm.edu
|
| Organization name |
Baylor College of Medicine
|
| Street address |
1 Baylor Plaza
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (8)
|
| GSM774636 |
WT mouse heart at 6-weeks old, biological rep1 |
| GSM774637 |
WT mouse heart at 6-weeks old, biological rep2 |
| GSM774638 |
WT mouse heart at 6-weeks old, biological rep3 |
| GSM774639 |
WT mouse heart at 6-weeks old, biological rep4 |
| GSM774640 |
KO mouse heart at 6-weeks old, biological rep1 |
| GSM774646 |
KO mouse heart at 6-weeks old, biological rep2 |
| GSM774647 |
KO mouse heart at 6-weeks old, biological rep3 |
| GSM774649 |
KO mouse heart at 6-weeks old, biological rep4 |
|
| Relations |
| BioProject |
PRJNA146063 |
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