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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 10, 2011 |
| Title |
Genome wide gene expression profiles of distal colon from 5% DSS-treated mice after administration of various siRNA against TNFa. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Differential gene expression assessed in siTNF-OMe-P treated animals showed significant correlation between improved colon integrity and clinical parameters of colitis with reduced TLR activation, tissue regeneration and reduced pro-inflammatory cytokines, as compared to all treatment groups.
This data shows the changes in gene expression profile associated with effective silencing of TNFa by a chemically-modified siRNA in the colon of colitic mice.
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| Overall design |
We performed genome-wide gene expression profiling of 5% DSS-treated mice after intrarectal administration of a)siRNA against TNFa (siTNF), b)siRNA against TNFa modified with O-Methyl nucleotides (siTNF-OMe), c)siRNA against TNFa modified with O-Methyl-propanediol nucleotides (siTNF-OMe-P) and d) siControl (scrambled siRNA).
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| Contributor(s) |
Perales JC, Eritja R, Ocampo SM |
| Citation(s) |
22044934 |
| Submission date |
Sep 06, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Evarist Planet Letschert |
| E-mail(s) |
evarist.planet@irbbarcelona.org
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| Organization name |
IRB Barcelona
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| Department |
Biostatistics
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| Street address |
C/ Baldiri Reixac 10
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| City |
Barcelona |
| State/province |
Spain |
| ZIP/Postal code |
08028 |
| Country |
Spain |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (36)
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| GSM790910 |
Control, replicate 4 |
| GSM790911 |
Control, replicate 5 |
| GSM790912 |
Control, replicate 6 |
| GSM790913 |
Control, replicate 7 |
| GSM790914 |
Control, replicate 8 |
| GSM790915 |
Control, replicate 9 |
| GSM790916 |
SiRNA-scrambled, replicate 1 |
| GSM790917 |
SiRNA-scrambled, replicate 2 |
| GSM790918 |
SiRNA-scrambled, replicate 3 |
| GSM790919 |
SiRNA-scrambled, replicate 4 |
| GSM790920 |
SiRNA-scrambled, replicate 5 |
| GSM790921 |
SiRNA-scrambled, replicate 6 |
| GSM790922 |
SiRNA-scrambled, replicate 7 |
| GSM790923 |
TNFa siRNA-A, replicate 1 |
| GSM790924 |
TNFa siRNA-A, replicate 2 |
| GSM790925 |
TNFa siRNA-A, replicate 3 |
| GSM790926 |
TNFa siRNA-A, replicate 4 |
| GSM790927 |
TNFa siRNA-A, replicate 5 |
| GSM790928 |
TNFa siRNA-A, replicate 6 |
| GSM790929 |
TNFa-OMe siRNA-B, replicate 1 |
| GSM790930 |
TNFa-OMe siRNA-B, replicate 2 |
| GSM790931 |
TNFa-OMe siRNA-B, replicate 3 |
| GSM790932 |
TNFa-OMe siRNA-B, replicate 4 |
| GSM790933 |
TNFa-OMe siRNA-B, replicate 5 |
| GSM790934 |
TNFa-OMe siRNA-B, replicate 6 |
| GSM790935 |
TNFa-OMe-P siRNA-C, replicate 1 |
| GSM790936 |
TNFa-OMe-P siRNA-C, replicate 2 |
| GSM790937 |
TNFa-OMe-P siRNA-C, replicate 3 |
| GSM790938 |
TNFa-OMe-P siRNA-C, replicate 4 |
| GSM790939 |
TNFa-OMe-P siRNA-C, replicate 5 |
| GSM790940 |
TNFa-OMe-P siRNA-C, replicate 6 |
| GSM790941 |
TNFa-OMe-P siRNA-C, replicate 7 |
| GSM790942 |
TNFa-OMe-P siRNA-C, replicate 8 |
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| Relations |
| BioProject |
PRJNA145221 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE31906_RAW.tar |
172.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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