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| Status |
Public on Nov 02, 2011 |
| Title |
Identification of the epithelial receptor for measles virus |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Measles (MV) is an aerosol-transmitted virus that affects more than 10 million children each year and accounts for approximately 120,000 deaths. While it was long believed to replicate in the respiratory epithelium before disseminating, it was recently shown to initially infect macrophages and dendritic cells of the airways using the signaling lymphocytic activation molecule (SLAM, CD150) as receptor. These cells then cross the respiratory epithelium and ferry the infection to lymphatic organs where MV replicates vigorously. How and where the virus crosses back into the airways has remained unknown. However, certain carcinoma cell lines have been described to be either permissive for wt MV infection, or not (Leonard VHJ et al. 2008). Therefor, we decided to compare the expression pattern of permissive and non-permissive cell lines by micro array analysis. Based on functional analyses of surface proteins preferentially expressed on virus-permissive epithelial cell lines, we identified nectin-4 (poliovirus-receptor-like-4) as a candidate receptor.
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| Overall design |
The dataset comprises 21 samples divided into seven sample groups each representing 3 biological replicates of one out of 7 cell lines.
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| Contributor(s) |
Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, Ramachandran S, McCray PB, Cichutek K, von Messling V, Lopez M, Cattaneo R |
| Citation(s) |
22048310 |
| Submission date |
Sep 15, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Michael Mühlebach |
| E-mail(s) |
Michael.Muehlebach@pei.de
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| Phone |
+49 - 6103 - 77 4005
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| Fax |
+49 - 6103 - 77 1255
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| Organization name |
Paul-Ehrlich-Institut
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| Street address |
Paul-Ehrlich-Strasse 51-59
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| City |
Langen |
| ZIP/Postal code |
63225 |
| Country |
Germany |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (21)
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| GSM796760 |
human lung adenocarcinoma cell line a - non-permissive for MVwt - cultured - biol rep 1 |
| GSM796761 |
human lung adenocarcinoma cell line a - non-permissive for MVwt - cultured - biol rep 2 |
| GSM796762 |
human lung adenocarcinoma cell line a - non-permissive for MVwt - cultured - biol rep 3 |
| GSM796763 |
human lung adenocarcinoma cell line b - non-permissive for MVwt - cultured - biol rep 1 |
| GSM796764 |
human lung adenocarcinoma cell line b - non-permissive for MVwt - cultured - biol rep 2 |
| GSM796765 |
human lung adenocarcinoma cell line b - non-permissive for MVwt - cultured - biol rep 3 |
| GSM796766 |
human urinary bladder squamous carcinoma cell line - non-permissive for MVwt - cultured - biol rep 1 |
| GSM796767 |
human urinary bladder squamous carcinoma cell line - non-permissive for MVwt - cultured - biol rep 2 |
| GSM796768 |
human urinary bladder squamous carcinoma cell line - non-permissive for MVwt - cultured - biol rep 3 |
| GSM796769 |
human urinary bladder transitional cell carcinoma cell line - non-permissive for MVwt - cultured - biol rep 1 |
| GSM796770 |
human urinary bladder transitional cell carcinoma cell line - non-permissive for MVwt - cultured - biol rep 2 |
| GSM796771 |
human urinary bladder transitional cell carcinoma cell line - non-permissive for MVwt - cultured - biol rep 3 |
| GSM796772 |
human lung bronchioalveolar carcinoma cell line - permissive for MVwt - cultured - biol rep 1 |
| GSM796773 |
human lung bronchioalveolar carcinoma cell line - permissive for MVwt - cultured - biol rep 2 |
| GSM796774 |
human lung bronchioalveolar carcinoma cell line - permissive for MVwt - cultured - biol rep 3 |
| GSM796775 |
human lung papillary adenocarcinoma cell line - permissive for MVwt - cultured - biol rep 1 |
| GSM796776 |
human lung papillary adenocarcinoma cell line - permissive for MVwt - cultured - biol rep 2 |
| GSM796777 |
human lung papillary adenocarcinoma cell line - permissive for MVwt - cultured - biol rep 3 |
| GSM796778 |
human urinary bladder grade 3 carcinoma cell line - permissive for MVwt - cultured - biol rep 1 |
| GSM796779 |
human urinary bladder grade 3 carcinoma cell line - permissive for MVwt - cultured - biol rep 2 |
| GSM796780 |
human urinary bladder grade 3 carcinoma cell line - permissive for MVwt - cultured - biol rep 3 |
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| Relations |
| BioProject |
PRJNA147629 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32155_RAW.tar |
190.0 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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