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| Status |
Public on Jun 01, 2012 |
| Title |
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
In this study, we employed massively parallel sequencing technology to identify miRNAs expressed in B-cells from Ashkenazi Jewish centenarians, i.e., those living to a hundred and a human model of exceptional longevity, and younger controls without a family history of longevity. With data from 26.7 million reads comprising 9.4x108 bp from 3 centenarian and 3 control individuals, we discovered a total of 276 known miRNAs and 8 unknown miRNAs ranging several orders of magnitude in expression levels. A total of 22 miRNAs were found to be significantly upregulated, with only 2 miRNAs downregulated, in centenarians as compared to controls.
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| |
|
| Overall design |
Examination of miRNA profile of two different ages
|
| |
|
| Contributor(s) |
Suh Y |
| Citation(s) |
22846614 |
| Submission date |
Sep 29, 2011 |
| Last update date |
May 15, 2019 |
| Contact name |
Saurabh Gombar |
| E-mail(s) |
saurabh.gombar@med.einstein.yu.edu
|
| Organization name |
Albert Einstein College of Medicine
|
| Department |
Systems and Computational Biology
|
| Lab |
Yousin Suh
|
| Street address |
1301 Morris Park Avenue
|
| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9115 |
Illumina Genome Analyzer II (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| SRA |
SRP008552 |
| BioProject |
PRJNA147763 |
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