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| Status |
Public on May 13, 2012 |
| Title |
Expression data for effector T cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we examined differential gene expression in naïve human CD4+ T cells, as well as in effector Th1, Th17-negative and Th17-enriched CD4- T cell subsets. We observed a marked enrichment for increased gene expression in effector CD4+ T cells compared to naive CD4+ among immune-mediated disease oci genes. Within effector T cells, expression of disease-associated genes was increased in Th17-enriched compared to Th17-negative cells.
We used microarray to examine the gene expresssion profile and level of human naïve, Th1 and effector T cell subsets.
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| Overall design |
Human PBMCs were isolated and sorted to naïve, CD161-CCR6- and CD161+CCR6+ memory T cells. Naïve T cells were differentiatied to Th1 cells, and CD161-CCR6- and CD161+CCR6+ memory T cells were in vitro expanded for Th17-negative and Th17-enriched effector T cells. The gene profile was compared among naive, Th1, Th17-negative, and Th17-enriched cell subsets.
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| Contributor(s) |
Zhang W, Ferguson J, Cho J |
| Citation(s) |
22715389 |
| Submission date |
Oct 11, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Wei Zhang |
| E-mail(s) |
wei.zhang.wz73@yale.edu
|
| Phone |
203-737-1354
|
| Fax |
203-785-7273
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| Organization name |
Yale School of Medicine
|
| Lab |
Zhang
|
| Street address |
333 cedar st., P.O. Box 208019
|
| City |
New Haven |
| State/province |
Connecticut |
| ZIP/Postal code |
06405 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA146505 |
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