|
| Status |
Public on Jan 11, 2012 |
| Title |
Anti-Inflammatory Effects of Epidermal Growth Factor on the Immature Human Intestine |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The inflammatory response of preterm infants' intestine underlines its inability to respond to hemodynamic stress, microbes and nutrients. Recent evidence suggests that exogenous epidermal growth factor (EGF) exerts a therapeutic influence on neonatal enteropathies. However, the molecular mechanisms underlying the beneficial effects of EGF remain to be clarified. The purpose of this study was to evaluate the impact of EGF on the gene expression profiles of the developing human small and large intestine at mid-gestation in serum-free organ cultures using Illumina microarrays.
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| |
|
| Overall design |
Differential functional effects of EGF along the human fetal intestine [Illumina]
Transcriptional profiling of small and large intestinal explants cultured in the absence (control) or in the presence of EGF (50 ng/mL).
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| |
|
| Contributor(s) |
Ménard D, Tremblay E, Ferretti E, Corentin B, Seidman E, Beaulieu J |
| Citation(s) |
22214601 |
| Submission date |
Nov 18, 2011 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Jean-François Beaulieu |
| E-mail(s) |
Jean-Francois.Beaulieu@Usherbrooke.ca
|
| Organization name |
Université de Sherbrooke
|
| Department |
Anatomie & biologie cellulaire
|
| Street address |
3001, 12ème avenue nord
|
| City |
Sherbrooke |
| State/province |
Québec |
| ZIP/Postal code |
J1H 5N4 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA148125 |
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