|
| Status |
Public on Feb 06, 2012 |
| Title |
CDDP treatment of U2OS cells with NCOR and SMRT knock-down |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We detected an interaction between checkpoint kinase Chk2 and some members of the NCOR/SMRT co-repressor complex. In order to study the role of gene repression in the checkpoint response to DNA damage, we performed RNA profiling in NCOR or SMRT knockdown cells after treztment with cisplatin.
|
| |
|
| Overall design |
U2OS cells were transfected with siRNAs for NCOR or SMRT, grown for 2 days in complete medium, and then treated with 100 microM cisplatin (CDDP) for 6h. Biological duplicates were used for RNa profiling
|
| |
|
| Contributor(s) |
Scafoglio C, Krones A, Ohgi K, Smolka M, Zhou H, Rosenfeld MG |
| Citation(s) |
23690919 |
| Submission date |
Dec 07, 2011 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Claudio Scafoglio |
| E-mail(s) |
cscafoglio@ucsd.edu
|
| Organization name |
University of California san Diego
|
| Street address |
9500 Gilman drive, CMM-W room 345, MC0648
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6884 |
Illumina HumanWG-6 v3.0 expression beadchip |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA149781 |
Less...
More...