|
| Status |
Public on Apr 04, 2012 |
| Title |
Effects of Cardiac Glycosides on RNA Expression in Prostate Cancer LNCaP-abl Cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Prostate cancer is the most common cancer in men and cardiac glycosides inhibit prostate cancer cell proliferation. In order to investigate the mechanism by which cardiac glycosides inhibit prostate cancer cells, we observed genome-wide RNA expression in prostate cancer LNCaP-abl cells, hormone resistant cells, after the cardiac glycoside treatment using RNA-Seq. In addition, we profiled LNCaP-abl cells after androgen receptor (AR) knockdown to observe whether cardiac glycoside effect on RNA expression is similar to that of AR knockdown.
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| |
|
| Overall design |
Observation of three cardioglycosides, Digoxin, Peruvoside and Strophanthidin, and AR knockdown regulated RNA expression in LNCaP-abl with RNA-Seq (each triplicates)
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| |
|
| Contributor(s) |
Li H, Fu X |
| Citation(s) |
22396588 |
| Submission date |
Jan 16, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Hai-Ri Li |
| E-mail(s) |
hairili@ucsd.edu
|
| Phone |
858-534-4926
|
| Organization name |
University of California, San Diego
|
| Department |
Medicine
|
| Lab |
Dr. Francesca Telese
|
| Street address |
9500 Gilman Dr.
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL9115 |
Illumina Genome Analyzer II (Homo sapiens) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (18)
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|
| Relations |
| SRA |
SRP010350 |
| BioProject |
PRJNA150723 |
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