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| Status |
Public on Jan 28, 2012 |
| Title |
Genome-wide gene expression analysis of HL60 cells and its alpha particle-resistant derivative RA11, gamma resistant-derivative RG8, and vincristine resistant-derivative RV+ at baseline and following 8Gy gamma IR and ~2Gy alpha IR |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The purpose of this study was to identify genes that were differentially expressed in radiation-sensitive, naïve HL60 cells, and the derivatives created in our laboratory as indicated in the 'sample title'. We wanted to identify genes that were differentially expressed both before and after ionizing radiation (IR) exposure, from both a single dose of gamma rays and a single dose of alpha particles, at 4h following IR exposure. The data were used to identify genes that could be driving radioresistance in each respective cell line.
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| Overall design |
The four cell lines, HL60, RA11, RG8, and RV+ were all analyzed at control (0Gy) radiation dose, 8Gy gamma rays, and ~2Gy alpha particles. Samples were collected from each cell line, for each dose, 4h following radiation exposure. The samples were collected from three independent experiments from three consecutive days in cell culture.
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| Contributor(s) |
Haro KJ, Scheinberg DA |
| Citation(s) |
23155415 |
| Submission date |
Jan 27, 2012 |
| Last update date |
Feb 13, 2020 |
| Contact name |
Kurtis Haro |
| Organization name |
MSKCC
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| Street address |
1275 York Ave
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (36)
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| Relations |
| BioProject |
PRJNA152603 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE35372_RAW.tar |
6.2 Mb |
(http)(custom) |
TAR |
| GSE35372_README.txt |
1.0 Kb |
(ftp)(http) |
TXT |
| GSE35372_significant_genes_list.txt.gz |
62.9 Kb |
(ftp)(http) |
TXT |
| Processed data not provided for this record |
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