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| Status |
Public on Oct 01, 2012 |
| Title |
The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of the extent to which inter-individual variation in mRNA decay contributes to inter-individual variation in gene expression levels in humans. The study examines properties of genome-wide decay rates and the relationship between mRNA decay and gene expression across genes, across individuals, and finally across genotype classes.
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| Overall design |
70 human lymphoblastoid cell lines were treated with Actinomycin D to arrest transcription. Transcript abundance was measured at 5 timepoints: before transcription (0 hours) and after transcription (0.5 hours, 1 hour, 2 hours, and 4 hours). Data was then used to estimate gene-specific decay rates genome-wide.
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| Contributor(s) |
Pai AA, Cain CE, Mizrahi-Main O, De Leon S, Lewellen N, Veyrieras J, Degner JF, Gaffney DJ, Pickrell JK, Stephens M, Pritchard JK, Gilad Y |
| Citation(s) |
23071454 |
| Submission date |
Apr 20, 2012 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Athma A Pai |
| E-mail(s) |
athma@uchicago.edu
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| Organization name |
University of Chicago
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| Street address |
920 E. 58th Street
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| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60637 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (350)
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| Relations |
| BioProject |
PRJNA160139 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE37451_RAW.tar |
26.2 Mb |
(http)(custom) |
TAR |
| GSE37451_non-normalized.txt.gz |
95.9 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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