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Series GSE37951 Query DataSets for GSE37951
Status Public on May 14, 2012
Title Acute host transcriptonal response to r1918 influenza and r1918 influenza containing the NS1 gene from A/Texas/36/91 in A549 cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The “Spanish influenza” of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transcriptional response to the eight-gene 1918 virus. To better understand the role of the 1918 virus NS1 gene, we also evaluated the host response to fully reconstructed 1918 and reassortant 1918 virus containing the NS1 gene from A/Texas/36/91 (a seasonal isolate of human influenza virus).
 
Overall design A549 cells were infected with either recombinant 1918 influenza, a chimeric virus that contained seven genes from recombinant 1918 and the NS1 from A/Texas/36/91 (Tx/91), or mock. Cells were harvested for microarray analysis at 2, 6, and 24hr following infection.
 
Contributor(s) Billharz R, Zeng H, Proll SC, Korth MJ, Lederer S, Albrecht R, Goodman AG, Rosenzweig E, Tumpey TM, Garcia-Sastre A, Katze MG
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Submission date May 14, 2012
Last update date Jan 23, 2019
Contact name Michael Katze
E-mail(s) data@viromics.washington.edu
Organization name University of Washington
Department Microbiology
Lab Michael G. Katze, Ph.D
Street address Rosen Building 960 Republican St.
City Seattle
State/province WA
ZIP/Postal code 98109-4325
Country USA
 
Platforms (1)
GPL6480 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Samples (64)
GSM930834 7:1 24hr 1 vs. Mock 24hr pool (251485029630_1_3)
GSM930835 7:1 24hr 1 vs. Mock 24hr pool (251485029630_1_4)
GSM930836 7:1 24hr 2 vs. Mock 24hr pool (251485029631_1_3)
Relations
BioProject PRJNA165829

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37951_RAW.tar 977.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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