|
| Status |
Public on May 31, 2012 |
| Title |
c-Met regulation of tumor initiation and stemness occurs through CD44s |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
c-Met induces tumor initiation and stemness in HCC cells through the regulation of CD44s via AKT signaling. Over-expression of CD44s in c-Met and CD44s negative cells induce both a stemness and mesenchymal phenotype independent of c-Met.
|
| |
|
| Overall design |
The down regulation of CD44s or c-Met was compared to Scrambled control to investigate the effects of CD44s or c-Met on global changes of mesenchymal or stemness markers.
|
| |
|
| Contributor(s) |
Dang H, Steinway SN, Ding W, Rountree CB |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 30, 2012 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Penn State COM |
| Organization name |
Penn State College of Medicine
|
| Department |
Genome Sciences Facility
|
| Street address |
500 University Drive
|
| City |
Hershey |
| State/province |
PA |
| ZIP/Postal code |
17033 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (9)
|
| GSM940337 |
MHCC97-H CD44s shRNA (7165895079_G) |
| GSM940338 |
MHCC97-H CD44s shRNA (7165895058_A) |
| GSM940339 |
MHCC97-H CD44s shRNA (7165895058_K) |
| GSM940340 |
MHCC97-H Scrm shRNA (7165895079_J) |
| GSM940341 |
MHCC97-H Scrm shRNA (7165895079_L) |
| GSM940342 |
MHCC97-H Scrm shRNA (7165895058_C) |
| GSM940343 |
MHCC97-H c-Met shRNA (7166142057_H) |
| GSM940344 |
MHCC97-H c-Met shRNA (7165895058_H) |
| GSM940345 |
MHCC97-H c-Met shRNA (7165895058_L) |
|
| Relations |
| BioProject |
PRJNA167762 |
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