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| Status |
Public on Apr 01, 2015 |
| Title |
Methylation profiling of oral squamous cell carcinoma (OSCC) |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
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| Summary |
According to epidemiological studies, a vast majority, approximately 80%~90% of male OSCC patients in Taiwan habitually drink alcohol (A), and chew betel quid (B), and use cigarette (C). To assess the impact of these dietary factors on the epigenome, we conduct a high-throughput screen survey in an oral cancer cohort with exposure of A, B, and C. Results indicate aberrent methylation patterns are prevalent in OSCC patients with ABC risk factors.
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| Overall design |
Genomic DNA was collected from tumor and non-tumor pair-wise samples. These biopsies were obtained from 40 male OSCC patients who regularly drink alcohol, chew areca nut and smoking.
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| Contributor(s) |
Lee C, Chang C, Hsiao J |
| Citation(s) |
23624915, 26317789 |
| Submission date |
Jun 06, 2012 |
| Last update date |
Jul 26, 2019 |
| Contact name |
Chia Huei Lee |
| E-mail(s) |
chlee124@nhri.edu.tw
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| Organization name |
Taiwan National Health Research Institute
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| Department |
National Institute of Cancer Research
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| Street address |
35, Keyan Rd.
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| City |
Zhunan Miaoli County |
| ZIP/Postal code |
114 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL8490 |
Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2) |
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| Samples (80)
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| Relations |
| BioProject |
PRJNA168110 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE38532_RAW.tar |
5.8 Mb |
(http)(custom) |
TAR |
| GSE38532_non-normalized.txt.gz |
10.9 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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