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| Status |
Public on Jul 19, 2012 |
| Title |
B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Anaysis of the response to different therapeutic agents at the transcriptional level. The design of the experiment allows to determine how the comnination target therapy (Rapamycin + PD0325901) treatment shifted the transcriptome towards a less aggressive or even a wild type phenotype. It also allows exploring the molecular changes involved in the transition from a non metastatic to a metastatic prostate cancer mouse model.
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| Overall design |
Total RNA obtained form vehicle treated Nkx3.1CE2/+; Ptenf/f; BrafCA/+ (n=3), combinatorial Rapamycin and PD0325901 treated Nkx3.1CE2/+; Ptenf/f; BrafCA/+ (n=3) and vehicle treated intact Nkx3.1CE2/+; Ptenf/f (n = 6) prostate. Please contact Cory Abate-Shen (cabateshen@columbia.edu) and Jingqiang Wang (jw2639@columbia.edu) for questions about the submission.
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| Contributor(s) |
Wang J, Kobayashi T, Floch N, Kinkade CW, Aytes A, Dankort D, Lefebvre C, Mitrofanova A, Cardiff RD, McMahon M, Califano A, Shen MM, Abate-Shen C |
| Citation(s) |
22836754 |
| Submission date |
Jul 09, 2012 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Antonina Mitrofanova |
| E-mail(s) |
mitrofanova.antonina@hotmail.com
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| Organization name |
Rutgers University
|
| Street address |
65 Bergen Street, Rm 923B
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| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07107 |
| Country |
USA |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (12)
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| GSM957722 |
Nkx3.1CE2/+; Ptenf/f (4) |
| GSM957723 |
Nkx3.1CE2/+; Ptenf/f (5) |
| GSM957724 |
Nkx3.1CE2/+; Ptenf/f (6) |
| GSM957725 |
Nkx3.1CE2/+; Ptenf/f; BrafCA/+ (1) |
| GSM957726 |
Nkx3.1CE2/+; Ptenf/f; BrafCA/+ (2) |
| GSM957727 |
Nkx3.1CE2/+; Ptenf/f; BrafCA/+ (3) |
| GSM957728 |
Nkx3.1CE2/+; Ptenf/f; BrafCA/+ (RAPPD treated)(1) |
| GSM957729 |
Nkx3.1CE2/+; Ptenf/f; BrafCA/+ (RAPPD treated)(2) |
| GSM957730 |
Nkx3.1CE2/+; Ptenf/f; BrafCA/+ (RAPPD treated)(3) |
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| Relations |
| BioProject |
PRJNA170931 |
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