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| Status |
Public on Jul 24, 2012 |
| Title |
Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Expression profiling of Prdm1 mutant E9.5 placenta was performed using Illumina whole genome V2 arrays. The hypothesis tested in the present study was that Blimp1 regulates the transcription of key genes involved in trophoblast differentiation. We demonstrate that the invading SpA-TGCs display robust Blimp1 expression and Blimp1 functional loss selectively disrupts specification of this discrete TGC sub-type. Transcriptional profiling experiments identified additional SpA-TGC lineage restricted marker genes that potentially regulate placental morphogenesis.
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| Overall design |
Prdm1BEH/+ (Vincent et al., 2005) animals were intercrossed to generate null placental tissue. Total RNA obtained from 10 Prdm1+/+ and 11 Prdm1-/- E9.5 placenta samples was hybridized to Illumina WG6_V2 beadchips.
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| Contributor(s) |
Mould A, Morgan M, Li L, Bikoff E, Robertson E |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 23, 2012 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Arne Wyndham Mould |
| E-mail(s) |
arne.mould@psych.ox.ac.uk
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| Organization name |
Oxford University
|
| Department |
Psychiatry
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| Lab |
Neural Correlates of Gene Function
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| Street address |
Warneford Hospital
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| City |
Oxford |
| State/province |
Oxfordshire |
| ZIP/Postal code |
OX3 7JX |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (21)
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| Relations |
| BioProject |
PRJNA171158 |
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