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| Status |
Public on Aug 04, 2012 |
| Title |
5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (Jejunum) |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
Male Sprague-Dawley rats [Crl:CD®(SD)IGS BR], weighing ~250 g at study initiation were obtained from Charles River Laboratories, Inc. (Wilmington, MA). Rats were housed singly in ventilated, stainless steel, wire-bottom hanging cages and fed non-certified Rodent Chow (Harlan Labs, Madison, WI) and water ad libitum and acclimated for at least 5 days after arrival. Rats were randomly assigned to various treatment groups (3 rats/group) and were dosed once daily by oral gavage with vehicle (0.2% hydroxypropylmethylcellulose at a dose volume of 10 ml/kg) or with 30, 100, or 200 mg/kg of A-998679. All rats were fasted overnight after their last dose, weighed and sacrificed under isoflurane anesthesia. Liver and small intestine (jejunum) were flash frozen in liquid nitrogen and stored at −80°C until processing for gene expression profiling on the Affymetrix platform.
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| Overall design |
total of 11 samples, 3 biological replicates (rats) from each of 3 treatments groups 1. vehicle control 2. 30mg/kg A-998679 3. 100mg/kg A-998679 and 2 biological replicates from treatment group 4. 200mg/kg A-998679
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| Contributor(s) |
Liguori M, Ciurlionis R |
| Citation(s) |
23112805 |
| Submission date |
Aug 02, 2012 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Rita Ciurlionis |
| E-mail(s) |
rita.ciurlionis@abbvie.com
|
| Phone |
(847)935-6258
|
| Organization name |
Abbvie
|
| Street address |
1 North Waukegan Road
|
| City |
North Chicago |
| State/province |
IL |
| ZIP/Postal code |
60064 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE39875 |
5 Day Oral Study of A-998679 in Male Sprague Dawley Rats |
|
| Relations |
| BioProject |
PRJNA171928 |
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