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Series GSE40032 Query DataSets for GSE40032
Status Public on Aug 15, 2015
Title Epigenetic silencing of HAND2 is a crucial step in endometrial carcinogenesis
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Here we demonstrate that epigenetic silencing of HAND2 is a key step in endometrial carcinogenesis. We performed an epigenome-wide methylation analysis of >27,000 CpG sites in endometrial cancers and controls and identified methylation of HAND2 as one of the most common hypermethylated and silenced genes in endometrial cancer.
 
Overall design Bisulphite converted DNA from the 87 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2.
 
Contributor(s) Jones A, Teschendorff AE, Li Q, Mould T, Zikan M, Cibula D, Fiegl H, Lee S, Wik E, Hadwin R, Arora R, Lemech C, Turunen H, Pakarinen P, Jacobs IJ, Salvesen H, Bagchi MK, Bagchi IC, Widschwendter M
Citation(s) 24265601
Submission date Aug 10, 2012
Last update date Aug 08, 2019
Contact name Shahzia Anjum
Organization name University College London
Street address Gower Street
City London
ZIP/Postal code WC1E 6BT
Country United Kingdom
 
Platforms (1)
GPL8490 Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)
Samples (87)
GSM983959 frozen tissue from endometrial cancer samples [4974911001_J]
GSM983960 frozen tissue from endometrial cancer samples [4974911005_D]
GSM983961 frozen tissue from endometrial cancer samples [4974911005_K]
Relations
BioProject PRJNA172423

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40032_RAW.tar 5.8 Mb (http)(custom) TAR
Processed data included within Sample table
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