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| Status |
Public on Oct 28, 2012 |
| Title |
Transcriptional analysis of whole blood in patients with auto-inflammatory disorders |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
HOIL1 deficient disease is a new early onset fatal autosomal recessive human disorder charaterized by chronic auto-inflammation, recurrent invasive bacterial infections and progressive muscular amylopectinosis. We studied the transcriptional profiles of whole blood from one HOIL dificient patient and other auto-inflammatory patients, including CINCA, Muckle-Wells syndrome and MVK deficiency.
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| Overall design |
Whole blood was collected in Tempus tubes from 41 healthy children and patients with CINCA (2), MWS (5), MVK deficiency (2) and HOIL deficiency (1) diseases. RNA was extracted and globin reduced. Labeled cRNA was hybridized to Illumina Human HT-12 Beadchips.
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| Citation(s) |
23104095 |
| Submission date |
Sep 03, 2012 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Zhaohui Xu |
| Organization name |
St. Jude Children's Research Hospital
|
| Department |
Infectious Diseases
|
| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (51)
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| This SubSeries is part of SuperSeries: |
| GSE40752 |
Transcriptional analysis of whole blood, primary fibroblasts, and PBMCs upon TNF-alpha or IL-1beta stimulation from HOIL-1-deficient patients |
|
| Relations |
| BioProject |
PRJNA174576 |
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