|
| Status |
Public on Sep 06, 2012 |
| Title |
Genome-wide analysis of tumor regression upon K-RAS inactivation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We performed expression profiling on micro-dissected lung tumors derived from a doxycycline-inducible K-RAS mouse model in order to gain mechanistic insight into K-RAS-mediated tumor maintenance. In this model, the tumors were induced with doxycycline for 11 weeks (in order to obtain lung tumors). At this point the doxycyline was withrawn from the food of the mice and consequently K-RAS inactivated. Thus, the genome-wide analysis was performed on tumors at timepoints 0, 24h and 48h after K-RAS inactivation.
|
| |
|
| Overall design |
Total RNA obtained from mouse lung tumors at time 0 and 24h or 48h after K-RAS inactivation.
|
| |
|
| Contributor(s) |
Scaglioni PP, Konstantinidou G, Yang C, Batten K, Schuster K, Shay JW, DeBerardinis RJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 05, 2012 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Kimberly Batten |
| E-mail(s) |
kimberly.batten@UTSouthwestern.edu
|
| Organization name |
UT Southwestern Medical Center
|
| Department |
Cell biology
|
| Lab |
Shay/Wright
|
| Street address |
5323 Harry Hines Blvd
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
73509 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (12)
|
| GSM997779 |
mutant K-ras on [4825641011_D] |
| GSM997780 |
mutant K-ras off 48h [4825641011_E] |
| GSM997781 |
mutant K-ras off 48h [4825641011_F] |
| GSM997782 |
mutant K-ras off 48h [4825641012_A] |
| GSM997783 |
mutant K-ras off 48h [4825641012_B] |
| GSM997784 |
mutant K-ras off 24h [4825641012_C] |
| GSM997785 |
mutant K-ras off 24h [4825641012_D] |
| GSM997786 |
mutant K-ras off 24h [4825641012_E] |
| GSM997787 |
mutant K-ras off 24h [4825641012_F] |
|
| Relations |
| BioProject |
PRJNA174390 |
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