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| Status |
Public on Sep 30, 2013 |
| Title |
The SNAI1 and SNAI2 embryonic genes are reactivated in numerous cancer types, including carcinomas |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The SNAI1 and SNAI2 embryonic genes are reactivated in numerous cancer types, including carcinomas. They promote cancer cell dissemination by inducing an epithelial-to-mesenchymal transition (EMT) and by protecting cells from anoikis. We now have demonstrated that the sequentially related SNAI3 gene is aberrantly reactivated in human breast carcinomas. To compare the functional properties of the three SNAIL family members, the transcription factors were ectopically expressed in immortalized mammary epithelial cells.
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| Overall design |
Immortalized human mammary epithelial cells (HMEC-hTERT cells) or MCF10A cells were infected with SNAIL retroviral expression constructs. The gene expression profiles of the resulting cell lines, cultured in standard conditions or after plating them 24h in low-adherent (LA) conditions, were performed.
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| Contributor(s) |
Barbet F, Carrere M, Gras B, Wierinckx A, Puisieux A, Ansieau S |
| Citation(s) |
24638100 |
| Submission date |
Sep 07, 2012 |
| Last update date |
Aug 13, 2018 |
| Contact name |
stéphane ansieau |
| E-mail(s) |
ansieau@lyon.fnclcc.fr
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| Phone |
0033-478785160
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| Fax |
0033-478782821
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| Organization name |
Inserm U590
|
| Department |
Centre Léon Bérard
|
| Street address |
28 rue Laennec
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| City |
Lyon |
| ZIP/Postal code |
69008 |
| Country |
France |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA174625 |
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