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| Status |
Public on Nov 21, 2013 |
| Title |
Deep sequencing of the small RNA transcriptome of blood leukocytes from Parkinson's disease patients prior to and following deep brain stimulation (DBS) and as compared with healthy control volunteers |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
We report the application of small RNA sequencing technology for high-throughput profiling of microRNA molecules (miRNAs) in blood leukocytes of Parkinson's Disease (PD) patients. Expression changes which may contribute to PD pathogenesis and reaction to treatment were identified in RNA preparations from blood leukocyte samples collected from PD patients prior to and following DBS neurosurgery on stimulation and following a short one hour cessation of the electrical stimulation (which enabled dissociation of the surgery effects from the electrical stimulation alone) and from matched healthy control volunteers, all under signed informed consents.
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| Overall design |
Examination of four states: Parkinson's Disease (PD) patients 1 day prior to DBS, PD patients a few weeks after DBS neurosurgery (upon symptoms stabilization) both on and following one hour electrical stimulation cessation, and age-matched healthy control volunteers.
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| Contributor(s) |
Soreq L, Bergman H, Bronstein M, Israel Z, Soreq H |
| Citation(s) |
23717260 |
| Submission date |
Sep 15, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Lilach Soreq |
| E-mail(s) |
l.soreq@ucl.ac.uk
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| Phone |
+44 07938689793
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| Organization name |
UCL
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| Department |
Molecular Neuroscience
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| Lab |
Prof. John Hardy
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| Street address |
Queen Square
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| City |
London |
| ZIP/Postal code |
WC1N 3BG |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL9442 |
AB SOLiD System 3.0 (Homo sapiens) |
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| Samples (12)
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| GSM1015762 |
Healthy control (HC) volunteer, sample 1 |
| GSM1015763 |
Healthy control (HC) volunteer, sample 2 |
| GSM1015764 |
Healthy control (HC) volunteer, sample 3 |
| GSM1015765 |
Parkinson's Disease (PD) patient, pre-DBS, sample 4 |
| GSM1015766 |
Parkinson's Disease (PD) patient, post-DBS on electrical stimulation (ON-Stim), sample 5 |
| GSM1015767 |
Parkinson's Disease (PD) patient, post-DBS following 1 hour off electrical stimulation (OFF-Stim), sample 6 |
| GSM1015768 |
Parkinson's Disease (PD) patient, pre-DBS, sample 7 |
| GSM1015769 |
Parkinson's Disease (PD) patient, post-DBS on electrical stimulation (ON-Stim), sample 8 |
| GSM1015770 |
Parkinson's Disease (PD) patient, post-DBS following 1 hour off electrical stimulation (OFF-Stim), sample 9 |
| GSM1015771 |
Parkinson's Disease (PD) patient, pre-DBS, sample 10 |
| GSM1015772 |
Parkinson's Disease (PD) patient, post-DBS on electrical stimulation (ON-Stim), sample 11 |
| GSM1015773 |
Parkinson's Disease (PD) patient, post-DBS following 1 hour off electrical stimulation (OFF-Stim), sample 12 |
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| Relations |
| BioProject |
PRJNA176709 |
| SRA |
SRP016008 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE40915_RAW.tar |
55.2 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE40915_supplementary_table_miRNA-star.txt.gz |
4.1 Kb |
(ftp)(http) |
TXT |
| GSE40915_supplementary_table_miRNA.txt.gz |
8.8 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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