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Series GSE40931 Query DataSets for GSE40931
Status Public on Sep 01, 2013
Title Genome-wide analysis of mRNA expression alterations of mucosa associated lymphoid tissue lymphoma translocation gene 1 (Malt1) -/- or Wild Type (WT) Naïve T cells induced to differentiate into (T helper) Th1 or Th17 cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary Microarrays were used to examine gene expression changes at two time points following the induction of differentiation of Malt1 deficient Naive T cells into Th1 or Th17 cells. The present study aims to find the effect that Malt1 deficiency has on lineage specific T cell differentiation. Malt1 is a NF kappa B regulator and plays a key role in peripheral T cell activation and proliferation, but its role in T cell differentiation is not clear. Aspects of the latter are what the current data set investigates.
 
Overall design Total RNA obtained from naïve T cells at two time points following induction to lineage specific T helper cells.
 
Contributor(s) Brenner D, Brustle A, Virtanen C, Mak TW
Citation(s) 23114599
Submission date Sep 17, 2012
Last update date Aug 23, 2019
Contact name carl virtanen
E-mail(s) cvirtane@uhnresearch.ca
Organization name University Health Network
Department Princess Margaret Genomics Centre
Street address 101 College St
City Toronto
State/province Ontario
ZIP/Postal code M5G 1L7
Country Canada
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (40)
GSM1005199 Malt1 -/- TH1 Cells 72 hours after induction from Naïve T cells Replicate 1
GSM1005200 WT TH17 Cells 48 hours after induction from Naïve T cells Replicate 1
GSM1005201 Malt1 -/- TH17 Cells 72 hours after induction from Naïve T cells Replicate 1
Relations
BioProject PRJNA175387

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40931_RAW.tar 15.8 Mb (http)(custom) TAR
GSE40931_non-normalized.txt.gz 7.2 Mb (ftp)(http) TXT
Processed data included within Sample table

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