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Status |
Public on Jan 29, 2006 |
Title |
Effect of ionizing radiation on procoagulant activity |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Ionizing radiation (IR) is associated with thrombotic vascular occlusion. Thrombosis in malignancy predicts a poor clinical outcome. Tissue factor (TF) is the initiator of the extrinsic co-agulation system and induces thrombus formation. Our study examined whether IR induced TF expression and procoagulability in the myelomonocytic leukemia THP-1 cell model. We further investigated coordinated gene alterations associated with TF upregulation and IR-induced thrombogenicity. Gene expression profiling revealed IR to increase the expression of inflammatory and apoptosis-related pathways, contributing to TF upregulation and increased TF procoagulability on day 7 post IR. The upregulation of these pathways together with TF upregulation contributed to the increased thrombogenic potential of tissues post application of IR. Keywords: irridiation response
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Overall design |
THP-1 cells were harvested on day 3 (1 sample) and day 7 (3 samples) post irradiation. For each time point untreated control samples were run.
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Contributor(s) |
Goldin-Lang P, Wittchen F, Witt H |
Citation(s) |
17640852 |
Submission date |
Jan 27, 2006 |
Last update date |
Mar 25, 2019 |
Contact name |
Henning Witt |
E-mail(s) |
witt@molgen.mpg.de
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Phone |
++49-30-450578727
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Organization name |
Max Planck Institute for Molecular Genetics
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Department |
Hans Lehrach
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Lab |
Patricia Ruiz
|
Street address |
Ihnestrasse 65
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City |
Berlin |
ZIP/Postal code |
14195 |
Country |
Germany |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (8)
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Relations |
BioProject |
PRJNA94931 |