|
| Status |
Public on Oct 12, 2012 |
| Title |
Genome-wide analysis of the SNAPc complex [Illumina array] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The small nuclear RNA (snRNA)-activating protein complex (SNAPc) is a basal transcription factor that mediates the transcriptional activation of snRNAs. Here, we describe the genome-wide occupancy of the SNAPC1_and SNAPC4 subunits of SNAPc. While the SNAPC4 occupancy was in accord with the role for SNAPc in snRNA transcription, SNAPC1_displayed a broader genomic profile mirroring that of RNA polymerase II at highly active protein-coding genes. Our functional analysis revealed a role for SNAPC1_in regulation of both basal and activator-induced transcription of protein-coding genes. These studies expand the role for SNAPC1_beyond its regulation of snRNA transcription.
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| |
|
| Overall design |
EGF stimulation of Hela cells, transfected with a control sh (scr) or a SNAPC1_sh
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| |
|
| Contributor(s) |
Gardini A, Shiekhattar R |
| Citation(s) |
22966203 |
| Submission date |
Oct 12, 2012 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Alessandro Gardini |
| E-mail(s) |
agardini@wistar.org
|
| Phone |
305-243-7394
|
| Organization name |
University of Miami
|
| Department |
Sylvester Comprehensive Cancer Center
|
| Lab |
Ramin Shiekhattar
|
| Street address |
1501 NW 10 Avenue
|
| City |
Miami |
| State/province |
FL |
| ZIP/Postal code |
33136 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (12)
|
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| This SubSeries is part of SuperSeries: |
| GSE41529 |
Genome-wide analysis of the SNAPc complex |
|
| Relations |
| BioProject |
PRJNA177368 |
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