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| Status |
Public on Jul 24, 2013 |
| Title |
Genome wide occupancy of SUMO machinery in proliferative and Ras-induced senescent human primary fibroblasts |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Transcription factors represent one of the largest groups of proteins regulated by SUMO, and their modification has generally been correlated with transcriptional repression. However, as most of the studies focus on specific sumoylated transcriptional regulators, the distribution and global role of SUMO on chromatin in relation to transcription regulation remain largely unknown. To investigate this role, we determined the occupancy of SUMO machinery proteins on chromatin by ChIP coupled to sequencing in human primary cells.
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| Overall design |
Examination of 3 histone modifications, Polymerase II, SUMO1, SUMO2, Ubc9 and PIASy in proliferative and Ras-induced senescent fibroblasts.
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| Contributor(s) |
Neyret-Kahn H, Benhamed M, Ye T, Le Gras S, Lapaquette P, Ouspenskaia M, Dasso M, Seeler J, Davidson I, Dejean A |
| Citation(s) |
23893515 |
| Submission date |
Nov 09, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Tao YE |
| Organization name |
IGBMC (CNRS/INSERM/UDS)
|
| Street address |
1 rue Laurent Fries
|
| City |
Illkirch |
| ZIP/Postal code |
67404 |
| Country |
France |
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| Platforms (2) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE42213 |
SUMO is an Integral and Instructive Component of Chromatin in Cell Growth and Senescence |
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| Relations |
| BioProject |
PRJNA179304 |
| SRA |
SRP017141 |
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