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| Status |
Public on Sep 22, 2014 |
| Title |
Expression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or those irradiated with an acute dose. Microarray profiling was perfromed on whole lungs from K-rasLA1 mice in order to determine global expression changes in the lung following radiation exposure. RNA was extracted from K-rasLA1 lungs from unirradiated control animals or those irradiated with a fractionated or acute dose of 1.0Gy 56Fe- particles 70 days post-irradiation when lungs are still histologically indistiguishable and only contain benign lesions.
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| Overall design |
129S2 K-rasLA1 mice were either irradiated with an acute (1.0Gy x1; n = 15) or fractionated (0.2Gy x5; n=13) dose of 1.0Gy 56Fe- particles or left unirradiated (n=13). Animals were euthanized 70 days post-irradiation and RNA was extracted from the whole left lung of each animal.
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| Contributor(s) |
Delgado O, Batten KG, Shay JW |
| Citation(s) |
24486591 |
| Submission date |
Nov 13, 2012 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Kimberly Batten |
| E-mail(s) |
kimberly.batten@UTSouthwestern.edu
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| Organization name |
UT Southwestern Medical Center
|
| Department |
Cell biology
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| Lab |
Shay/Wright
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| Street address |
5323 Harry Hines Blvd
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| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
73509 |
| Country |
USA |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (42)
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| Relations |
| BioProject |
PRJNA179376 |
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