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Series GSE42700 Query DataSets for GSE42700
Status Public on Mar 06, 2013
Title Epigenome analysis of buccal cells from monozygotic and dizygotic twins
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Using the Infinium HM450 platform, we have performed a longitudinal study of DNA methylation at birth and age 18 months in DNA from buccal swabs from 10 monozygotic (MZ) and 5 dizygotic (DZ) twin pairs from the Peri/postnatal Epigenetic Twins Study (PETS) cohort.
 
Overall design Beta methylation measurements from bisulphite-converted DNA and raw intensity values from 53 samples. Samples were collected at birth ('_B') or 18 months ('_18m'). Data were preprocessed using the Minfi package in R by the 'illumina' method and normalized to control probes. Subset quantile normalization was performed on type 1 and type 2 probes. Probes failing P detection cutoff of <0.01 were removed. Probes on the X and Y chromosomes have been removed from the processed data. Outlier samples were removed. Between-array quantile normalization was performed to arrive at the final data set of 330168 probes and 53 samples.
 
Contributor(s) Martino DJ, Saffery R, Craig J
Citation(s) 23697701
Submission date Dec 03, 2012
Last update date Mar 22, 2019
Contact name David Martino
E-mail(s) david.martino@telethonkids.org.au
Phone 0863191635
Organization name Telethon Kids Institute
Street address Perth Childrens Hospital, 15 Hospital Avenue
City NEDLANDS
State/province Western Australia
ZIP/Postal code 6009
Country Australia
 
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (53)
GSM1048133 Buccal cell 18m twin 1, 1035
GSM1048134 Buccal cell Birth twin 1, 1035
GSM1048135 Buccal cell 18m twin 2, 1035
Relations
BioProject PRJNA182758

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42700_Methylated_Unmethylated_Signals.txt.gz 442.5 Mb (ftp)(http) TXT
GSE42700_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data included within Sample table
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