|
| Status |
Public on Apr 07, 2014 |
| Title |
The effects of M3 muscarinic receptor gene ablation on murine colon neoplasia and gene expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
In mice treated with azoxymethane (AOM), an intestine-selective carcinogen, both colon tumor number and size were robustly reduced in Chrm3-/- compared to WT mice. In the present study, a microarray approach was used to identify genes that might have mechanistic relevance regarding the effects of M3R expression and activation on colon neoplasia, and also to identify potential biomarkers and therapeutic targets for colon cancer
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| |
|
| Overall design |
Total RNA obtained from isolated colon tumor in WT mice compared to M3KO mice.
|
| |
|
| Contributor(s) |
Raufman J, Cheng K |
| Citation(s) |
24694019 |
| Submission date |
Jan 11, 2013 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Kunrong Cheng |
| E-mail(s) |
kcheng@medicine.umaryland.edu
|
| Phone |
410-706-3466
|
| Organization name |
University of Maryland Baltimore
|
| Street address |
22 S. Greene St., N3W62
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21201 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA186621 |
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