|
| Status |
Public on Jul 09, 2013 |
| Title |
Identification of genes involved in SHH subgroup medulloblastoma using murine whole-body Sleeping Beauty insertional mutagenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Ptch+/- mice, which are predisposed to SHH subgroup medulloblastoma, were mutagenised using the Sleeping Beauty transposon to identify genes which increase the frequency of medulloblastoma formation. Gene expression in tumours was assessed both to investigate their relationship to human subgroup tumours, and to identify genes where expression was altered by mutagenesis.
|
| |
|
| Overall design |
Total RNA isolated from tumours induced by SB mutagenesis were compared to normal cerebellum, tumours induced witout SB mutagenesis, and tumours from a distinct model of disease (GTML).
|
| |
|
| Contributor(s) |
Jackson MS, Clifford SC, Williamson D, Chesler L, AlAfghani H |
| Citation(s) |
24252690 |
| Submission date |
Feb 01, 2013 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Michael Stewart Jackson |
| E-mail(s) |
m.s.jackson@ncl.ac.uk
|
| Phone |
+44 191 241 8677
|
| Organization name |
Newcastle University
|
| Department |
Institute of Genetic Medicine
|
| Street address |
Central Parkway
|
| City |
Newcastle upon Tyne |
| ZIP/Postal code |
NE1 3BZ |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (48)
|
|
| Relations |
| BioProject |
PRJNA188311 |
Less...
More...