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| Status |
Public on May 08, 2013 |
| Title |
Serum microRNA expression as an early marker for breast cancer risk in prospectively collected samples from the Sister Study cohort |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
microRNAs are small, non-coding, single-stranded RNAs between 18-22 nucleotides long that regulate gene expression. Expression of microRNAs is altered in tumor compared to normal tissue; there is some evidence that these changes may be reflected in the serum of cancer cases compared to healthy individuals. This has yet to be examined in a prospective study where samples are collected before diagnosis.
We used Affymetrix arrays to examine serum miRNA expression profiles in 410 participants in the Sister Study, a prospective cohort study of 50,884 women. All women in the cohort had never been diagnosed with breast cancer at the time of enrollment.
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| |
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| Overall design |
We compared global miRNA expression patterns in 205 women who subsequently developed breast cancer and 205 women who remained breast cancer-free.
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| Contributor(s) |
Godrey A, Xu Z, Weinberg C, Getts R, Wade P, DeRoo L, Sandler D, Taylor J |
| Citation(s) |
23705859 |
| Submission date |
Feb 12, 2013 |
| Last update date |
May 02, 2017 |
| Contact name |
Zongli Xu |
| Organization name |
NIH/NIEHS
|
| Street address |
111 tw alexander Dr.
|
| City |
Research Triangle Park |
| ZIP/Postal code |
27709 |
| Country |
USA |
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| Platforms (1) |
| GPL14613 |
[miRNA-2] Affymetrix Multispecies miRNA-2 Array |
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| Samples (419)
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| Relations |
| BioProject |
PRJNA189285 |
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