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Series GSE44300 Query DataSets for GSE44300
Status Public on Feb 14, 2013
Title DNA profiling of human normal colon tissues
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary To study the field cancerization effect, we screened systemic metastasis-related CNVs from morphologically normal colon tissues adjacent to colon cancer that had systemic metastasis. 89 systemic metastasis-related CNVs, mainly consisting of migration and invasion-, morphology-, cell death and survival-related pathways, were selected. Noticeably, LIM and senescent cell antigen-like domains 2 (LIMS 2, PINCH2) showed copy number amplification and up-regulation of mRNA expression in the non-relapsed group compared to the systemic relapse group. Colon cancer cells had lower expression of PINCH2 protein and mRNA compared with normal epithelial colon cells.
 
Overall design Two-condition experiment: 41 colon normal tissue vs. control gDNA.
 
Contributor(s) Park CH, Chung HC
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Submission date Feb 13, 2013
Last update date Jun 20, 2013
Contact name Park Chan Hee
E-mail(s) haema@yuhs.ac
Phone 80222277650
Organization name Cancer Metastasis Research Center
Street address Shinchondong 134
City Seodaemun-gu
State/province Seoul
ZIP/Postal code 120-752
Country South Korea
 
Platforms (1)
GPL8841 Agilent-014950 Human Genome CGH Microarray 4x44K (Probe Name version)
Samples (41)
GSM1082762 Normal colon tissue, NBRCCC001
GSM1082763 Normal colon tissue, NBRCCC002
GSM1082764 Normal colon tissue, NBRCCC003
Relations
BioProject PRJNA189403

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE44300_RAW.tar 579.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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